Live vaccine against canine distemper (CDV),inf. hepatitis (CAV-1), inf. laryngotracheitis(CAV-2), parvovirosis (CPV-2), parainfluenza(CPIV-2) in dogs.
 NAMEANDADDRESS OF THE MARKETINGAUTHORISATION HOLDER AND OF THE MANUFACTURING AUTHORISATION HOLDER RESPONSIBLE FOR BATCH RELEASE, IF DIFFERENT
Bioveta, a. s., Komenského 212, 683 23,Ivanovice na Hané, Czech Republic
 NAME OF THE VETERINARYMEDICINAL PRODUCT
Biocan DHPPi lyophilisate for preparation of solution for injection
Live vaccine against canine distemper (CDV),inf. hepatitis (CAV-1), inf. laryngotracheitis(CAV-2), parvovirosis (CPV-2), parainfluenza(CPIV-2) in dogs.
3. STATEMENT OF THEACTIVE SUBSTANCE(S)AND OTHERINGREDIENT(S)
Composition - 1 ml:
a) Freeze-dried component:

Virus febris contagiosae canis                             min. 10^3.5

Virus laryngotracheitidis contagiosae canis        min. 10^3.0 

Parvovirus enteritidis canis                                  min. 10^3.0

Virus parainfluensis canis                                     min. 10^4.0
Nutrimentum pro lyophilisatione ad                   1 ml

b) Diluent
Aqua pro injectione                                             1 ml

Notes:
The vaccines in brackets (P, R, DP, DHPPi) – possibility of the alternative application of other vaccine of Biocan series.
The vaccines marked:  +C, +L, +LR – possibility of the simultaneous or combined application with other vaccines.
Further possible vaccinations: 
Biocan M plus – vaccine against Microsporum canis for dogs of age 8 weeks and above, Biocan B – vaccine against Lyme disease for dogs of age 12 weeks and above, 
Biocan T – vaccine against tetanus for dogs of age 12 weeks and above.
The vaccination scheme should be specified by the veterinarian in dependence on the infection situation and the level of the passive immunity obtained due to the colostric antibodies in the vaccinated individuals. Annual revaccination is recommended to maintain permanent immunity.

9.     ADVICE ON CORRECT ADMINISTRATION Only clinically healthy animals in a good nutrition condition can be vaccinated. Possible anti-parasitic treatment should be carried out at least 10 days before the vaccination. The vaccinated animals should not be trained or exercised for one week after the vaccination. When diluted, the vaccine shall be used immediately.
10.     WITHDRAWAL PERIOD

Not intended for food animals.
11. SPECIAL STORAGE PRECAUTIONS Keep out of the reach and sight of children. Store in a dry and dark place at the temperature of 2 - 8 °C.
Do not use after the expiry date stated on the label.
When diluted, the vaccine shall be used immediately.

12.     SPECIAL WARNING
None.
13.     SPECIAL PRECAUTIONS FOR THE DISPOSAL OF UNUSED PRODUCT OR WASTE MATERIALS, IF ANY
The packages and any remainders of the preparation are to be disposed of pursuant to the regulations in force.
14.     DATE ON WHICH THE PACKAGE 

LEAFLET WAS LAST APPROVED 10-5-2018

15. OTHER INFORMATION
Drug form: lyophilisate for preparation of solution for injection
Immunological properties: After being applied to the body of the vaccinated individual, the antigens present in the vaccine are recognized as extraneous elements and a number of defensive mechanisms in the body are activated (macrophages, opsonins, interleukins, B lymphocytes, etc.), in consequence of which specific antibodies against the antigen determinants contained in the vaccine start to form. The said mechanisms shall prevent from subsequent development of the infection after contagion. 
Package: 

A) Plastic box with 10 hollows

10 × 1 ml of vaccine Biocan DHPPi + 10 × 1 ml of diluent

The package insert is attached to each package.